Dr Spyros Darmanis

Spyros Darmanis carried out his PhD in the lab of Dr. Ulf Landegren in Uppsala University in Sweden. During his PhD, he worked on the development of protein detection assays and applied them in the identification of putative protein biomarkers that could serve as early diagnostic indicators of different diseases such as prostate cancer and cardiovascular disease. Continuing as a postdoctoral fellow in the same lab and realizing the importance of single cell studies, he developed the first assay to measure level of expression of large numbers of protein and RNA molecules from the same single cell. He then applied this novel technique to investigate in human glioma the heterogeneity of response to treatment with BMP4. Currently he is a postdoctoral fellow in the lab of Prof. Stephen Quake at Stanford University where he is using single cell RNA sequencing methods to investigate the heterogeneity in the adult and fetal human brain both in healthy and different disease states.